Most frequent questions and answers
Cannabis contains over 500 phytochemical compounds of which cannabinoids make up at least 100 of these compounds. And while some cannabinoids are psychoactive, others are not.
The Endocannabinoid System is a signaling network found within every mammalian species on Earth. It features two cannabinoid receptors, CB1 and CB2 receptors, which THC and CBD “dock” with to provide their therapeutic effects. These receptors are located within different parts of the body such as the central nervous system and immune system.
Our bodies have an entire regulatory system called the endocannabinoid system (ECS) or the endogenous cannabinoid system. It is the ECS that uses cannabinoids to transmit certain signals and regulate homeostasis within us – it serves to balance our mood, appetite, sleep and hormone production. Plantbasedcannabinoids have analogues in the human body; meaning, our bodies produce cannabinoids, too. Our cells have receptor sites for cannabinoids (CB-1 and CB-2) which help regulate our immune system.
CBD is what’s called the negative allosteric modulator. In other words, when THC is present it interferes with THC’s activity. THC acts directly on the cannabinoid receptors CB1. CBD, on the other hand, doesn’t tend to bind directly to what’s called the orthosteric site where THC binds. CBD binds on what’s called an allosteric site, another site on the receptor, which in turn alters the binding of THC thus interfering with the activity.
Yes. Several studies suggest that CBD is well tolerated and safe in humans at high doses and with chronic use. More studies need to be done to assess potential interactions with other drugs.
Terpenes are the essential oils found in cannabis that create the fragrances and mental effects of different strains. Each strain of cannabis has its own unique blend of terpenes, called the terpene profile. Terpenes have been shown to block some cannabinoid receptor sites in the brain while promoting cannabinoid binding in others. As a result, terpenes are believed to affect many aspects of how the brain takes in THC or CBD, while offering various therapeutic benefits of their own. Terpenes, such as Beta-Caryophyllene, contribute to what is termed the” Entourage effect”.
Beta-Caryophyllene is a sesquterepene found in large amounts in the essential oils of many different plants and spices. Beta-Caryophyllene is the major terpene found in Cannabis that selectively binds to the same site of the CB2 receptor as THC, leading to cellular activity and anti-inflammatory effects.
The “entourage effect” is defined as the broad-spectrum sense of wellness derived from consuming an unaltered or concentrated form of cannabis, i.e. all the natural chemicals found in cannabis are ingested simultaneously. Terpenes are one of the three primary components (CBD and THC being the other two) of Cannabis that are thought to contribute to this effect and the differences found between strains in their strength and effect. For example, CBD by itself performs different than CBD in conjunction with THC, and both perform differently when in the presence of terpenoids.
Vesisorb is a patented lipid-based delivery system that increases bioavailability of a bioactive that is fat soluble or has poor water solubility. Vesisorb forms nanosized water-soluble droplets (called micelles) that that allow the bioactive to cross the water layer of the GI track for absorption. Vesisorb also provides extended release of the bioactive over time.
Cognizin is a patented, branded form of Citicoline that is backed by clinical research. Cognizin helps support healthy brain metabolism, protects your neural structures against free radical damage and provides phospholipids essential to healthy brain function.
Citicholine (CDP Choline, cytidine diphosphate-choline) is a natural nutrient found in every cell of the body and especially vital to brain health. Citicholine has been shown to support memory, focus and mental clarity by increasing the levels of acetylcholine, a neurotransmitter which is present in various parts of the brain. Acetylcholine is required for proper memory and cognition as well as motor control.
Until recently, CBDa was thought to be a minor cannabinoid and only be a small part of the overall cannabinoid profile. Higher amounts have been seen in ruderalis strains and recent hybrids like Cannatonic C-6 and ACDC have elevated levels of CBDa at potentially higher levels than THCa. Just like THCa, when heated up CBDa decarboxylates; as THCa becomes THC, so CBDa becomes CBD. Like CBD, CBDa is not psychoactive. While there hasn’t been much research done on CBDa yet, the research that has been done is quite promising. It appears to have anti-emetic effects as well as anti-proliferative effects, making it ideal for fighting cancer.It also has been shown to be an anti-inflammatory and to possess anti-bacterial properties.
- Anti-Emetic – Reduces vomiting and nausea.
- Anti-inflammatory – Reduces inflammation systemically.
- Anti-Proliferative – Inhibits cancer cell growth.
- Anti-Bacterial – Slows bacterial growth.